Mailing List:2001-01-30 09, Re: Genetics, DNA, Y, by Lyn Legere

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Mailing List Archives > 2001-01-30 09, Re: Genetics, DNA, Y, by Lyn Legere

From: Lyn Legere <lynleg -at- bu.edu> Subject: Re: [WHITNEY-L] Genetics, DNA, Y Date: Tue, 30 Jan 2001 22:22:34 -0500 References: <Pine.A41.4.03.10101292047320.16440-100000@therock.mcg.edu> Dear Barry and Group, Thank you for the detailed explanation of the DNA process. It is a somewhat complex technology for those of us who are science-illiterate. Thank you for putting together the bits and pieces I have heard about into a reasonable and very understandable explanation. Lyn Legere Barry Whitney wrote: > On Mon, 29 Jan 2001, Victoria Whitney Landau wrote: > > > comments that stated that the Whitney blood would be so diluted among > > us that there is probably no statisically significant difference > > between all of us and the general population. > > Dear Cousins, > > At each generation, half of a parent's genes (alleles) are passed to each > child. If you are in the 11th generation below John Whitney the > immigrant, you inherited very little of your DNA from John (1/2 to the > 11th power). The exception is the Y chromosome, that males inherit intact > (for practical purposes) from their fathers. Each male Whitney of today > who is descended from John Whitney the immigrant has basically the same Y > chromosome as John had (perhaps one basepair per million having changed by > mutation at each generation). So it is conceivable that if John had some > uncommon haplotype of DNA markers on his Y chromsome, that that haplotype > could be used to show relationships among present-day Whitney males (to > show kinship to the John/Elinor line vs. Henry, for instance). > > The quality of DNA from old sources depends on how well it was preserved. > Very cold is helpful, and very dry is also good. In any case, DNA > retrieved from a long-buried ancestor would be expected to be of rather > poor quality (short fragments) and low quantity. It might still be > possible to do analyses based on PCR (DNA amplification) but not Southern > Blots (standard DNA fingerprinting). DNA can only be found in nucleated > cells. Thus, cut hair from a baby book or red blood cells would not be > useful as DNA sources. (Whole blood contains enough white cells to > provide DNA, and DNA can be prepared from hair bulbs pulled from the > scalp.) > > It is certainly possible to save DNA today for studies to be done in the > distant future. > > After the complete sequence of the Y chromosome is known and regions that > contain suitable degrees of variability have been identified, it will > probably be possible to do an interesting Whitney Y chromosome study. > > Yours, Barry > > John Barry-11 Whitney III > My Whitney Ancestry: <a href="http://members.tripod.com/~bwhitney/whitney.htm">http://members.tripod.com/~bwhitney/whitney.htm</a> > Genealogy Search Suggestions: <a href="http://members.tripod.com/~bwhitney/">http://members.tripod.com/~bwhitney/</a> > Genetics consultations: <a href="http://home.earthlink.net/~ultihealth/genetics/">http://home.earthlink.net/~ultihealth/genetics/</a> > ----------------------------------------------------------------------- > Generation Inherited > John-1 Genes > 2 0.5 > 3 0.25 > 4 0.125 > 5 0.0625 > 6 0.03125 > 7 0.015625 > 8 0.0078125 > 9 0.00390625 > 10 0.001953125 > 11 0.000976563 > 12 0.000488281 > 13 0.000244141 > 14 0.00012207


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